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目的:探讨拉莫三嗪对癫痫儿童脑电活动的影响。方法:给予首次确诊的56例癫痫儿童拉莫三嗪单药治疗,用药6个月前后行发作间期脑电图、脑电地形图检查及认知功能测试。结果:①拉莫三嗪单药治疗6个月后,癫痫患儿脑电地形图的α、β、δ频段相对功率无变化(P>0.05),而θ频段相对功率显著降低(P<0.05);10例癫痫患儿发作间期痫样放电完全消失,26例减少50%以上,18例减少小于50%,2例无变化。②发作间期痫样放电完全消失和减少50%以上的癫痫患儿认知功能明显改善(P<0.05),而痫样放电减少小于50%和无变化的癫痫患儿认知功能无变化(P>0.05)。结论:拉莫三嗪可使癫痫患儿发作间期痫样放电减少,且对脑电背景活动无影响,并可使脑电渐趋稳定和顺应性;发作间期痫样放电明显减少的癫痫患儿认知功能明显改善。
Objective: To investigate the effect of lamotrigine on electroencephalogram in children with epilepsy. Methods: Fifty-six patients with epilepsy were selected for lamotrigine monotherapy. Intermission EEG, EEG and cognitive function tests were performed 6 months before and after treatment. Results: ① After 6 months of lamotrigine monotherapy, the relative power of α, β, δ band in epileptic children showed no change (P> 0.05), while the relative power in θ band decreased significantly (P <0.05 ). Epileptiform discharges in 10 epileptic children disappeared completely, 26 cases decreased more than 50%, 18 cases decreased less than 50%, 2 cases had no change. (2) The cognitive function of children with epilepsy disappeared completely and decreased more than 50% in the interictal epileptiform discharge was significantly improved (P <0.05), while the cognitive function of epileptic children with epileptiform discharge less than 50% and no change was unchanged P> 0.05). Conclusions: Lamotrigine can reduce epileptiform discharge in children with epilepsy, and have no effect on the background activity of EEG, and make the EEG stable and compliant. Epilepsy with reduced epileptiform discharge during epileptic seizure Children’s cognitive function improved significantly.