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基因治疗脑血管疾病的主要目标是将cDNA引入一个血管或血管周围组织使之产生一种物质,这种物质自然调节着血管生长或改变其功能。目前能够把基因转递到血管的载体是病毒载体(腺病毒和反转录病毒retrovirus),带阳离子的DNA微脂粒复合体,病毒缀合物载体(含有病毒外衣的微脂粒)。基因治疗颅内外血管疾病主要是达到以下目的;(1)预防SAH后的血管痉挛;(2)刺激侧支血管的建立;(3)稳定动脉粥样硬化斑块;(4)抑制再狭窄。
The main goal of gene therapy for cerebrovascular disease is to introduce cDNA into a blood vessel or perivascular tissue to produce a substance that naturally regulates or alters its function. Vectors that are currently capable of delivering genes to the blood vessels are viral vectors (adenoviruses and retroviruses), cationic DNA micro-liposome complexes, and virus conjugate vectors (viral coat-containing liposomes). Gene therapy for extracranial vascular disease mainly to achieve the following purposes; (1) to prevent vasospasm after SAH; (2) to stimulate the collateral vessels established; (3) stable atherosclerotic plaque; (4) inhibit restenosis.