体内总胆固醇93%以上存在于细胞膜,仅7%以脂蛋白形式循环于血浆中.本文概述当前对脂蛋白代谢的认识,着重介绍在降低血浆胆固醇水平和心血管疾病易患性方面最有希望的代谢控制环节.血浆胆固醇代谢途径有三条:(1)外源性途径食物胆固醇同脂肪酸一起被肠上皮细胞内包摄入,合成乳糜微粒而分泌入淋巴管,再经胸导管进入血浆,随 More than 93% of total cholesterol in the body is present in the cell membrane and only 7% circulates in the plasma as lipoproteins.This paper outlines current understanding of lipoprotein metabolism, highlighting the most promising in lowering plasma cholesterol and cardiovascular disease susceptibility (1) Exogenous Pathway Cholesterol, together with fatty acids, is taken up by intestinal epithelial cells and synthesized into chylomicrons and secreted into the lymphatic vessels, which then enter the plasma through the thoracic duct