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对53例经手术切除的肺神经内分泌癌进行了病理形态学及临床生物学特性的研究,根据分化程度,神经内分泌癌可以分为三型:高分化型(类癌)、中分化型(不典型类癌)、低分化型(小细胞肺癌)。在临床生物学方面,手术时肿瘤体积,高分化型为6.91cm~3,中分化型为23.82cm~3,低分化型为31.32cm~3,差别显著(P<0.05);中位生存时间,高分化型为78~+个月,中分化型为30个月,低分化型为14个月,差异极其显著(P<0.001)。在病理形态学和超微结构上三型间亦明显不同,有加以区分的实际意义。
The pathological and clinical biological characteristics of 53 cases of surgically resected lung neuroendocrine carcinomas were studied. According to the degree of differentiation, neuroendocrine carcinomas can be divided into three types: well-differentiated (carcinoid), moderately differentiated (not Typical carcinoid), poorly differentiated (small cell lung cancer). In terms of clinical biology, the tumor volume at the time of surgery was 6.91cm~3 for highly differentiated, 23.82cm~3 for moderately differentiated, and 31.32cm~3 for poorly differentiated, with significant difference (P<0.05); median survival time The highly differentiated type was 78 to + months, the moderately differentiated type was 30 months, and the poorly differentiated type was 14 months, the difference was extremely significant (P<0.001). In the pathological morphology and ultrastructure, the three types are also obviously different, and there is a practical significance to distinguish them.