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目的探讨表皮生长因子受体1(EGFR)蛋白表达在宫颈癌发生、发展中的临床病理意义。方法采用免疫组化En Vision法检测120例宫颈癌组织、49例高级别上皮内瘤变(CIN_(2~3))、40例低级别上皮内瘤变(CIN_1)、37例正常宫颈组织中EGFR蛋白的表达,并进行比较分析。结果(1)正常宫颈、CIN_1、CIN孙宫颈癌组织中EGFR蛋白表达阳性率分别为10.8%(4/37)、12.5%(5/40)、42.9%(21/49)、89.2%(107/120)。宫颈癌组织中EGFR蛋白表达阳性率显著高于CIN_(2~3)、CIN_1及正常宫颈组织(均P<0.01);EGFR蛋白在CIN_(2~3)中表达显著高于CIN_1和正常宫颈组织(均P<0.01);CIN_1和正常宫颈组织之间EGFR蛋白表达阳性率无统计学差异(P>0.05)。(2)肿瘤浸润深度更深的宫颈癌患者宫颈癌组织中EGFR蛋白表达阳性率高于浸润深度较浅的患者(P<0.01)。结论EGFR在宫颈癌进展过程中起了重要作用,有望成为抗宫颈癌治疗的一个潜在生物学标志。
Objective To investigate the clinicopathological significance of the expression of epidermal growth factor receptor 1 (EGFR) in the development of cervical cancer. Methods 120 cases of cervical cancer, 49 cases of high grade intraepithelial neoplasia (CIN_ (2 ~ 3)), 40 cases of low grade intraepithelial neoplasia (CIN_1) and 37 cases of normal cervical tissue were detected by immunohistochemistry En Vision method EGFR protein expression, and comparative analysis. Results (1) The positive rates of EGFR protein in normal cervix, CIN_1 and CIN were 10.8% (4/37), 12.5% (5/40), 42.9% (21/49) and 89.2% / 120). The positive rates of EGFR protein in cervical cancer tissues were significantly higher than those in CIN_ (2 ~ 3), CIN_1 and normal cervical tissues (all P <0.01). The expression of EGFR protein in CIN_ (2 ~ 3) was significantly higher than that in CIN_1 and normal cervical tissues (All P <0.01). There was no significant difference in the positive rate of EGFR protein expression between CIN_1 and normal cervical tissues (P> 0.05). (2) The positive rate of EGFR protein in cervical cancer tissues with deeper tumor invasion was higher than that in patients with shallow depth of invasion (P <0.01). Conclusion EGFR plays an important role in the progression of cervical cancer and is expected to become a potential biological marker for the treatment of cervical cancer.