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Major advances have been made in every aspect of theinflammatory bowel diseases (IBDs) since the first edition ofInflammatory Bowel Disease in 1975. This 5th edition featuresnew information on the molecular basis of intestinal epithelialfunction, including epithelial permeability, the impact of theenteric microflora on the gut mucosal immune system,neuroimmune interactions, the nature of oral tolerance, andthe M cell. Epidemiologic studies have further highlighted therole of the environment in the pathogenesis of IBD. New
Major advances have been made in every aspect of the inflammatory bowel diseases (IBDs) since the first edition of Inflammatory Bowel Disease in 1975. This 5th edition features new information on the molecular basis of intestinal epithelial function, including epithelial permeability, the impact of theenteric microflora on the gut mucosal immune system, neuroimmune interactions, the nature of oral tolerance, and the M cell. Epidemiologic studies have further highlighted therole of the environment in the pathogenesis of IBD. New