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本文用SPRIA检测了99个家庭424人血清标本的乙型肝炎病毒(HBV)感染标记,并用二项分布理论分析了HBsAg携带者、抗-HBs和抗-HBc阳性者以及HBV感染者的家庭分布规律。结果显示,HBsAg携带者的家庭分布不符合二项分布,提示有家庭聚集性;而抗-HBs、抗-HBc阳性者以及HBV感染者的家庭分布符合二项分布,无家庭聚集性。HBV感染标记的家庭分布规律不同,提示不同家庭的成员获得HBV持续感染和获得抗HBV感染的免疫力的机理是不同的。作者推测,遗传因素可能是造成HBsAg携带者呈家庭聚集性的主导因素之一。
In this paper, we detected the hepatitis B virus (HBV) infection markers of 424 serum samples from 99 families using SPRIA and analyzed the distribution of families with HBsAg carriers, anti-HBs and anti-HBc positive persons and HBV infected persons using binomial distribution theory law. The results showed that the family distribution of HBsAg carriers did not fit binomial distribution, suggesting that there was familial aggregation. However, the distribution of families with anti-HBs, anti-HBc positive and HBV-infected persons was binomial and had no family aggregation. Differences in the distribution of HBV-infected families suggest that different members of the family have different mechanisms of acquiring persistent HBV infection and acquiring immunity against HBV infection. The authors speculate that genetic factors may be one of the leading factors in the family aggregation of HBsAg carriers.