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目的：观察HFRS（Ⅰ型）鼠脑纯化灭活疫苗全程和加强免疫后18个月的流行病学。血清学效果。方法：采用免疫荧光法检测微量细胞病变试验，分别检测血清中的特异性抗体及中和抗体。结果：全程免疫后15天，中和抗体阳性率为40％，GMT为4．06；360天降为阴性，GMT为2.50；加强后2周抗体阳性率为50％，GMT为4.35.全程免疫后15天IFA抗体阳性率为100％，GMT为81．75；至360天阳性率降至12．50％，GMT为5．69；加强后2周阳性率升至81．25％，GMT为1297。加强免疫6363例，仅2例出现弱反应，无中、强反应。免后18个月经流行病学调查，1年内（经春、秋两个流行高峰）接种组发病2例，发病率为19.12／10万；对照组发病12例，发病率为74.06／10万，保护率为74.18％，保护指数为3.87；加强1针后的6个月中，接种组无病例，对照组发病3例，发病率47.15／10万，保护率达100％。结论：该疫苗安全性好；有较好的免疫应答；近期和中期流行病学防病效果良好。
OBJECTIVE: To observe the epidemiology of HFRS (type Ⅰ) brain purified inactivated vaccine whole-dose and 18-month post-boost immunization. Serological effects. Methods: The immunofluorescence method was used to detect the trace of cytopathic effect, and the serum specific antibodies and neutralizing antibodies were detected respectively. Results: Fifteen days after the whole immunization, the positive rate of neutralizing antibody was 40%, the GMT was 4.06, the level of GMT was 4.06, the GMT was 2.50, the positive rate of antibody was 50% and GMT was 4.35 After 15 days, the positive rate of IFA antibody was 100% and the GMT was 81.75; the positive rate was reduced to 12.50% and the GMT was 5.69 by 360 days; the positive rate rose to 81.25% 1297. Strengthen the immune 6363 cases, only 2 cases appeared weak reaction, no, strong reaction. In the 18-month period after immunization, epidemiological investigation showed that 2 cases were inoculated in one year (the two epidemic peak in spring and autumn), the incidence was 19.12 / 100000; in the control group, 12 cases were found, the incidence was 74.06 / The protection rate was 74.18%, and the protection index was 3.87. In the 6 months after strengthening 1 st needle, there were no cases in the vaccinated group and 3 cases in the control group, the incidence rate was 47.15 / 100000 with a protection rate of 100%. Conclusion: The vaccine is safe and has a good immune response. The epidemiology of the vaccine has good effect in the short and medium term.