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目的:观察HFRS(Ⅰ型)鼠脑纯化灭活疫苗全程和加强免疫后18个月的流行病学。血清学效果。方法:采用免疫荧光法检测微量细胞病变试验,分别检测血清中的特异性抗体及中和抗体。结果:全程免疫后15天,中和抗体阳性率为40%,GMT为4.06;360天降为阴性,GMT为2.50;加强后2周抗体阳性率为50%,GMT为4.35.全程免疫后15天IFA抗体阳性率为100%,GMT为81.75;至360天阳性率降至12.50%,GMT为5.69;加强后2周阳性率升至81.25%,GMT为1297。加强免疫6363例,仅2例出现弱反应,无中、强反应。免后18个月经流行病学调查,1年内(经春、秋两个流行高峰)接种组发病2例,发病率为19.12/10万;对照组发病12例,发病率为74.06/10万,保护率为74.18%,保护指数为3.87;加强1针后的6个月中,接种组无病例,对照组发病3例,发病率47.15/10万,保护率达100%。结论:该疫苗安全性好;有较好的免疫应答;近期和中期流行病学防病效果良好。
OBJECTIVE: To observe the epidemiology of HFRS (type Ⅰ) brain purified inactivated vaccine whole-dose and 18-month post-boost immunization. Serological effects. Methods: The immunofluorescence method was used to detect the trace of cytopathic effect, and the serum specific antibodies and neutralizing antibodies were detected respectively. Results: Fifteen days after the whole immunization, the positive rate of neutralizing antibody was 40%, the GMT was 4.06, the level of GMT was 4.06, the GMT was 2.50, the positive rate of antibody was 50% and GMT was 4.35 After 15 days, the positive rate of IFA antibody was 100% and the GMT was 81.75; the positive rate was reduced to 12.50% and the GMT was 5.69 by 360 days; the positive rate rose to 81.25% 1297. Strengthen the immune 6363 cases, only 2 cases appeared weak reaction, no, strong reaction. In the 18-month period after immunization, epidemiological investigation showed that 2 cases were inoculated in one year (the two epidemic peak in spring and autumn), the incidence was 19.12 / 100000; in the control group, 12 cases were found, the incidence was 74.06 / The protection rate was 74.18%, and the protection index was 3.87. In the 6 months after strengthening 1 st needle, there were no cases in the vaccinated group and 3 cases in the control group, the incidence rate was 47.15 / 100000 with a protection rate of 100%. Conclusion: The vaccine is safe and has a good immune response. The epidemiology of the vaccine has good effect in the short and medium term.