应用液氮冷冻喷雾法、棉签法及冷刀法按不同时间冷冻家兔及豚鼠皮肤后,间隔不同时间取材,观察冷冻处的病理改变。发现两者病理改变相同,即先出现表皮坏死、真皮有大量中性白细胞成堆浸润、胶原纤维肿胀、血管扩张、管腔内充满红细胞、随后出现皮内出血和皮肤深部的炎症反应。 Application of liquid nitrogen frozen spray method, cotton swab method and cold knife method frozen at different times in rabbits and guinea pig skin, at different intervals drawn, observe the frozen pathological changes. Found that the pathological changes of both the same, that is, first appeared epidermal necrosis, a large number of neutrophils in the dermis piles infiltration, collagen fibers swollen, vasodilation, lumen filled with red blood cells, followed by intradermal bleeding and deep skin inflammation.