肾小球肾炎是成人慢性HBV感染少见的并发症,多数病人对干扰素治疗有短期反应,并伴随蛋白尿症的改善。作者的研究目的是评价α干扰素治疗HBV相关性肾小球肾炎的长期反应。 1985～1993年期间,有15例慢性乙型肝炎伴肾小球肾炎的病人被推荐到美国国立卫生研究院肝病科作评价和治疗。全部病人均有HBV感染证据和经肝活检确诊的慢性 Glomerulonephritis is a rare complication of chronic HBV infection in adults. Most patients have a short-term response to interferon therapy and are associated with an improvement in proteinuria. The authors’ study aimed to evaluate the long-term response of interferon-alpha to HBV-associated glomerulonephritis. Between 1985 and 1993, 15 patients with chronic hepatitis B with glomerulonephritis were referred to the National Institutes of Health for evaluation and treatment of liver disease. All patients had evidence of HBV infection and chronic liver biopsy diagnosed