M树脂与Boc保护的亮氨酸、甘氨酸或苯丙氨酸的铝盐成酯反应摩尔比1:12,时间31h,其产物用重量法和水杨醛法测得的结合率均值分别为87.3％、89.1％和89.6％。王氏树脂与Fmoc保护的亮氨酸、甘氨酸或苯丙氨酸反应48h,树脂:Fmoc氨基酸:DCC:DMAP摩尔比为1:3:4:1,其产物结合率的均值分别为44.2％、30.4％和56.2%。结果表明,前者产物结合率高于后者。另外,重量法与水杨醛法测得的结合率相差不超过2.7％,但重量法更方便,易行。 The molar ratio of M resin to Boc-protected aluminum salt of leucine, glycine or phenylalanine was 1:12 and 31 h, respectively, and the average binding rates of its products by gravimetric method and salicylaldehyde method were 87.3% 89.1% and 89.6%. Wang resin reacted with Fmoc-protected leucine, glycine or phenylalanine for 48h. The average binding rate of resin: Fmoc amino acid: DCC: DMAP was 1: 3: 4: 1, 30.4% and 56.2%. The results show that the former product binding rate higher than the latter. In addition, the gravimetric method and salicylaldehyde method to determine the binding rate difference of not more than 2.7%, but the gravimetric method is more convenient and easy.