Significant Spike-Specific IgG and Neutralizing Antibodies in Mice Induced by a Novel Chimeric Virus

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Dear Editor,rnMiddle East respiratory syndrome coronavirus (MERS-CoV),first isolated in 2012,has emerged zoonotically among humans (van Boheemen et al.2012).Since then,MERS-CoV continues to be a public health concern,with a fatality rate of 35%.On-going MERS-CoV outbreaks highlight the urgent need for the development of interventional measures,including an effective vaccine against MERS-CoV infection.Currently,no licensed therapeutic or vaccine is available (Okba et al.2017).
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