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诊断方法的进展脑膜炎的病原学诊断至今仍存在不少问题,细菌培养需48～72小时方能生长,而20～40%的标本为阴性,脑脊液涂片找细菌约40%以上为阴性,部分治疗的化脓性脑膜炎因脑脊液中细菌数量减少,其涂片及培养的阳性率则更低;病毒分离需时2周左右,且60～80%为阴性。为了提高诊断的速度,目前国外做了不少工作。抗原的测定对流免疫电泳(CIE) 自1971年 Edward首先用该法诊断败血型流行性脑脊髓膜炎(流脑)以来,采用 CIE 诊断流脑、流感杆菌及肺炎双球菌脑膜炎的报告较多。据 Ogunbi 及
The progress of diagnostic methods There are still many problems in the etiological diagnosis of meningitis, bacterial culture takes 48 to 72 hours before growth, while 20 to 40% of the specimens were negative, about 40% of the bacterial smear of CSF was negative, Part of the treatment of purulent meningitis due to the reduction in the number of bacteria in the cerebrospinal fluid, the smear and culture positive rate is lower; virus separation takes about 2 weeks, and 60 to 80% negative. In order to improve the speed of diagnosis, a lot of work has been done abroad. Antigen Determination Convergence Immuno-Electrophoresis (CIE) Since 1971, when Edward first used this method to diagnose meningococcal meningitis (meningitis), the use of CIE to diagnose meningitis, meningococcal and pneumococcal meningitis has been reported more . According to Ogunbi and