疟原虫配子体在脊椎动物宿主的血液内不能发育成配子,而在蚊胃或在含有空气的相应条件下感染血液中则能迅速地发育成为配子。曾报道:小配子形成可发生在pH7.8和8.4含有葡萄糖和碳酸氢盐缓冲液中;还认为蚊胃内存在一种可以促进小配子形成的因素。本文研究是通过体外实验将疟原虫配子体放到磷酸二脂酶(PDE)抑制剂中,试评价这些化合物对疟原虫小配子形成所起的诱导作用。 Plasmodium gametophytes can not develop as gametes in the blood of vertebrate hosts and can rapidly develop into gametes in mosquitoes’ stomachs or in infected blood under the relevant conditions that contain air. It has been reported that the formation of the small gametes can occur in buffers containing glucose and bicarbonate at pH 7.8 and 8.4; and there is also a factor within the mosquito that can promote the formation of the gametes. This study investigated the induction of these compounds on the formation of malaria protozoa by in vitro experiments in which the malaria gametophyte was placed in a phosphodiesterase (PDE) inhibitor.