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目的 研究芦丁控释片的制备及体外释药特性。方法 以羟丙基甲基纤维素 (HPMC)、可压性淀粉 (pregelatinizedstarch)、微晶纤维素 (MCC)为辅料 ,采用粉末直接压片法制备缓释骨架片 ,以均匀设计法进行处方的筛选 ,并考察优选处方体外溶出特性。结果 HPMC用量越大 ,芦丁释放速率越慢 ,优化后处方体外释药符合Higuchi方程 ,控释片 1 0h体外释药 90 %左右 ,不同时间的释药参数分别为t0 .5 =4 .2 3h ,t0 .9 =1 0 .86h。结论 该片剂处方合理 ,制备工艺简单易行 ,适合工业化生产
Objective To study the preparation and in vitro release characteristics of rutin controlled-release tablets. Methods Hydroxypropyl methylcellulose (HPMC), pregelatinized starch, and microcrystalline cellulose (MCC) were used as excipients. Sustained-release matrix tablets were prepared by powder direct compression method. Screen and examine the in vitro dissolution characteristics of the preferred formulation. Results The greater the amount of HPMC, the slower the release rate of rutin. After the optimization, the in vitro release of the drug complied with the Higuchi equation. The controlled-release tablet was released in vitro by 90 % in vitro. The drug release parameters at different times were t 0 .5 =4.2. 3h ,t0 .9 =1 0 .86h. Conclusion The tablet prescription is reasonable, the preparation process is simple and easy for industrial production.