尿液内环境不稳定对尿中酶活性的表现不利,以致较长时间以来,尿酶及其同工酶的研究几乎处于停滞状态。近十多年来,由于实验方法及检测仪器的进展,尤其在1976年Wilkinson报告了与肾组织损伤有密切关连的酶在肾组织内的分布(见表1)以来,尿液作为一种能灵敏地反映机体脏器病变并极易获得的无创伤性检体,已越来越引起临床工作者的关注。1983年10月在东京召开的第 Urinary instability has adversely affected urinary enzyme activity, resulting in a nearly stagnant study of urinary enzymes and their isoenzymes over a long period of time. For more than a decade, due to the advances in experimental methods and instrumentation, especially since Wilkinson reported the distribution of the enzyme in renal tissues closely related to renal tissue injury in 1976 (see Table 1), urine as a Sensitive to reflect organ lesions and easily available noninvasive specimens, has drawn more and more clinicians attention. October 1983 held in Tokyo