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目的：探究参附注射液治疗休克的机制。方法：12只SD大鼠随机分为3组，生理盐水对照组、低剂量参附注射液组（5ml/kg）、高剂量参附注射液组（10ml/kg），腹腔注射给物。给药5min后，各组舌下静脉注射内毒素10mg/kg，建立感染性休克SD大鼠模型，分别于内毒素注射30、60、90、120分钟后测耳廓微循环血液灌注量（PU），运动血细胞浓度（CMBC）、血细胞运动速率（V）值。结果：注射内毒素后，相对于生理盐水对照组，低、高剂量参附注射液组的PU下降趋势均显著减小（P<0.05）、对CMBC及V有显著的升高作用（P<0.05）。结论：参附注射液能显著改善内毒素感染性休克SD大鼠的微循环。“,”Objective: To explore the Mechanism for the treatment of shock of Shenfu injection. Methods: 12 SD rats were randomly divided into control group of normal saline,low does group of Shenfu injection(5ml/kg), high does group of Shenfu injection(10ml/kg),intraperitoneal injection.Five minutes later, sublingual vein injection of endotoxin 10mg/kg,build a model of septic shock of SD rats.30、60、90、120 minutes later,PU,CMBC,V were measured.Results: after the injection of endotoxin, Compared with saline control group,decline of PU of low and high dose group of Shenfu injection were significantly decreased(P< 0.05).CMBC and V were significant rised in low and high dose group of Shenfu injection.Conclusion: Shenfu injection can significantly improve the microcirculation of endotoxin of septic shock of SD rats.