作者报告一个51岁有大空洞的肺结核患者,在按每千克体重用异菸肼9毫克达18克后,发生了严重的出血现象。患者有关节肿胀,皮肤紫斑,显微镜血尿及极强阳性的束臂现象(Rumpel-Leedes Phonomen)。把异菸肼量减到每千克体重5毫克仍有新血斑出现及指趾端的感觉异常。皮出血在停药3周后才停止,束臂现象到6周后仍为阳 The authors report that a 51-year-old patient with a large tuberculosis developed severe bleeding after consuming 18 grams of isoniazid at 18 grams per kilogram of body weight. Patients had swollen joints, purplish skin, microscopic hematuria, and a strongly positive fascia (Rumpel-Leedes Phonomen). The amount of isoniazid reduced to 5 mg / kg body weight there is still a new blood spot and the toe end of the sensory abnormalities. Bleeding in the skin stopped 3 weeks after the stop, beam arm phenomenon is still positive after 6 weeks