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目的检测乳腺癌、良性乳腺病变及正常乳腺组织中人乳腺珠蛋白(human mammaglobin,hMAM)的表达,探讨乳腺珠蛋白在乳腺各种病变中的临床应用价值,并与传统乳腺癌标志物进行比较。方法选取48例乳腺癌、26例良性乳腺疾病及10例正常乳腺组织标本,其石蜡切片进行免疫组化染色。结果乳腺癌、良性乳腺疾病及正常组织中,hMAM表达阳性率分别为72.9%、88.3%和40%。其表达与患者年龄、病理分型及肿瘤大小、分级、淋巴结转移等无关,而与孕激素受体(PR)呈负相关。结论乳腺珠蛋白在乳腺癌、良性病变及乳腺正常组织中均存在高表达,未发现其表达与乳腺癌预后等相关。
Objective To detect the expression of human mammaglobin (hMAM) in breast cancer, benign breast lesions and normal breast tissues and to investigate the clinical value of mammary gland globulin in various breast lesions and to compare with traditional breast cancer markers . Methods 48 cases of breast cancer, 26 cases of benign breast disease and 10 cases of normal breast tissue specimens were selected and paraffin sections were harvested for immunohistochemical staining. Results The positive rates of hMAM expression in breast cancer, benign breast disease and normal tissues were 72.9%, 88.3% and 40% respectively. The expression was not related with patient’s age, histopathology, tumor size, grading, lymph node metastasis, but negatively correlated with progesterone receptor (PR). Conclusion The expression of mammaglobin in breast cancer, benign lesions and normal breast tissues are highly expressed, and its expression is not associated with the prognosis of breast cancer.