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用流式细胞术测定163例人鼻咽癌前与癌细胞DNA含量,用DNA指数(DNA index)均值表示相对含量。以正常人淋巴细胞及人胎儿鼻咽上皮细胞DI为正常对照(DI=1.000);炎症、单纯增生及轻度异型增生细胞均正常(DI=1.023);中、重度异型增生DI值分别为1.181和1.27;癌细胞DI均值高达1.332,其中鳞癌细胞分化越差,DI值越高,异倍体百分比越高,高分化鳞癌DI均值1.325,异倍体率61.29%;低分比鳞癌DI均值为1.460,异倍体率90％。未分化癌DI均值为1.426,异倍体率100％。说明细胞恶变过程中,细胞恶性程度与DNA量呈正相关。并比较了癌组织生长方式与DNA量的关系。
Flow cytometry was used to determine the DNA content of 163 cases of human nasopharyngeal precancerous and cancerous cells, and the relative content was expressed as the mean of DNA index. Normal human lymphocytes and human fetal nasopharyngeal epithelial cells DI were normal controls (DI=1.000); inflammation, simple hyperplasia, and mild dysplasia were normal (DI=1.023); DI values of moderate to severe dysplasia were 1.181 respectively. And 1.27; cancer cell DI mean as high as 1.332, of which the poorer differentiation of squamous cell carcinoma, the higher the DI value, the higher the percentage of aneuploid, highly differentiated squamous cell carcinoma DI mean 1.325, anomalous rate of 61.29%; low score than squamous cell carcinoma The mean value of DI was 1.460, and the heteroploid rate was 90%. The mean undifferentiated cancer DI was 1.426 and the heteroploidy rate was 100%. It shows that the degree of malignancy of cells is positively correlated with the amount of DNA during malignant transformation of cells. The relationship between the growth pattern of cancer tissue and the amount of DNA was compared.