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[目的]探讨血清CA153、CEA、CYFRA21-1、TSGF联合检测对乳腺癌诊断的意义。[方法]采用电化学发光检测CA153、CEA、CYFRA21-1,化学比色法测定TSGF。[结果]乳腺癌患者血清CA153、CEA、CYFRA21-1和TSGF水平及阳性率均明显高于正常女性对照组及乳腺良性肿瘤对照组(P﹤0.05);联合检测的敏感性和诊断准确性均比单项检测高。[结论]联合检测血清中的CA153、CEA、CYFRA21-1、TSGF对乳腺癌的诊断具有重要的临床意义。
[Objective] To explore the significance of combined detection of serum CA153, CEA, CYFRA21-1 and TSGF in the diagnosis of breast cancer. [Methods] Electrochemiluminescence was used to detect CA153, CEA and CYFRA21-1. Chemical colorimetry was used to determine TSGF. [Results] The levels and positive rate of serum CA153, CEA, CYFRA21-1 and TSGF in breast cancer patients were significantly higher than those in normal women and benign breast tumors (P<0.05). The sensitivity and diagnostic accuracy of the combined detection were both. Higher than single test. [Conclusion] Combined detection of serum CA153, CEA, CYFRA21-1, TSGF has important clinical significance in the diagnosis of breast cancer.