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In this paper,we study the symmetry energy and the Wigner energy in the binding energy formula for atomic nuclei.We simultaneously extract the I2 symmetry energy and Wigner energy coefficients using the double difference of“experimental”symmetry-Wigner energies,based on the binding energy data of nuclei with A ≥ 16.Our study of the triple difference formula and the“experimental”symmetry-Wigner energy suggests that the macro-scopic isospin dependence of binding energies is explained well by the I2 symmetry energy and the Wigner energy,and further consideration of the I4 term in the binding energy formula does not substantially improve the calculation result.