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目的 研究肺癌患者手术前后血清STNFRI的变化。方法 采用ELISA方法测定了80例肺癌患者 ,14例非肿瘤患者 ,61例志愿健康成年人。结果 肺癌患者中STNFRI的平均水平明显高于健康对照组和非肿瘤组 (P<0.01)。按肿瘤TNM分期 ,肺癌Ⅲ～Ⅳ期患者远高于Ⅰ～Ⅱ期升高幅度 ,与疾病分期明显相关 ,而与病理类型无关 (P<0.01)。结论 排除自身免疫疾病和感染 ,STNFRI的测定对肿瘤的诊断 ,筛选 ,预后有辅助意义。也可了解病人的异常免疫状态 ,为肿瘤患者的免疫治疗提供依据及观察指标。
Objective To study the changes of serum STNFRI before and after surgery in patients with lung cancer. Methods 80 lung cancer patients, 14 non-tumor patients and 61 volunteer healthy adults were determined by ELISA. Results The average level of STNFRI in patients with lung cancer was significantly higher than that in the healthy and non-tumor groups (P<0.01). According to the tumor TNM staging, the patients with stage III to IV of lung cancer were significantly higher than those at stage I to II, which was significantly correlated with the stage of the disease, but not with the pathological type (P<0.01). Conclusions Excluding autoimmune diseases and infections, the determination of STNFRI is helpful for the diagnosis, screening, and prognosis of tumors. Can also understand the patient’s abnormal immune status, provide evidence and observation indicators for cancer patients with immunotherapy.