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目的:观察自拟中药方莪黄汤保留灌肠联合XELOX方案化疗对结、直肠癌组织血管生成因子(VEGF)表达的影响。方法:将治疗前30例患者作为对照组,行纤维结肠镜活检并保存肿瘤组织标本;然后随机分为2组各15例,均采用XELOX方案化疗,中药保留灌肠联合化疗组配合使用莪黄汤保留灌肠治疗。治疗后所有患者再次行肿瘤组织活检,并观察肿瘤组织中VEGF的表达情况。结果:化疗组、中药保留灌肠联合化疗组与对照组比较,肿瘤组织中VEGF的表达有一定下调;中药保留灌肠联合化疗组与化疗组比较,肿瘤组织中VEGF的表达稍有下调,但不明显。中药保留灌肠联合化疗可明显改善患者里急后重、腹痛等不适。结论:莪黄汤保留灌肠联合化疗能一定程度下调结、直肠癌组织中VEGF的表达。
OBJECTIVE: To observe the effect of reserpine Huangzitang retention enema combined with XELOX chemotherapy on the expression of angiogenic factor (VEGF) in the tissues of colorectal cancer and rectal cancer. Methods: The 30 patients before treatment as the control group were examined by fiberoptic colon biopsy and the tumor tissue specimens were preserved. Then they were randomly divided into two groups of 15 cases, all of which were treated with XELOX chemotherapy. The traditional Chinese medicine retention enema combined with chemotherapy group Enema treatment. After treatment, all the patients underwent biopsy of tumor tissue again and observe the expression of VEGF in tumor tissue. Results: Compared with the control group, the expression of VEGF in the chemotherapy group and the retention enema of the traditional Chinese medicine group was down-regulated. Compared with the chemotherapy group, the expression of VEGF in the retention enema and chemotherapy group was slightly down-regulated . Retention enema combined with chemotherapy can significantly improve patients with tenesmus, abdominal pain and other discomfort. Conclusion: The retention enema combined with chemotherapy can decrease the expression of VEGF in node and rectal cancer to a certain extent.