阿德福韦在体外和体内拥有很强的抗野生乙型肝炎病毒株的活性。这一研究旨在评价单独阿得夫伟治疗或联合拉米夫定治疗对那些慢性肝炎代偿期、对拉米夫定耐药的患者的安全性和疗效比较。方法 :5 9例对拉米夫定耐药患者 ,HBeAg阳性、血清ALT水平大于或等于正常高限的 1 2倍、血清 Adefovir has strong resistance to wild-type hepatitis B virus strains in vitro and in vivo. The aim of this study was to evaluate the safety and efficacy of adefovine alone or in combination with lamivudine in patients with chronic hepatitis with compensatory response to lamivudine. Methods: Ninety-nine patients with lamivudine-resistant, HBeAg-positive, serum ALT level greater than or equal to the normal high limit of 1 2 times, serum