【摘 要】
：
A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthesized compounds against three human prostate cancer
【机 构】
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College of Chemistry and Chemical Engineering, Luoyang Normal University,Pharmaceutical Research Cen
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthesized compounds against three human prostate cancer cell lines(PC-3, LNCa P, and DU145) were evaluated by a CCK-8 assay. Compounds 8, 10, 13, 17 and 20 exhibited strong cytotoxic activities against the tested cancer cell lines(IC_(50)<3 μmol/L). In addition, these compounds exhibited weak cytotoxic effects on human epithelial prostate normal cells WPMY-1. The structure–activity relationship(SAR) of these arylpiperazine derivatives was also discussed based on the obtained experimental data.
A series of novel arylpiperazine derivatives was synthesized. The in vitro cytotoxic activities of all synthetic compounds against three human prostate cancer cell lines (PC-3, LNCa P, and DU 145) were evaluated by a CCK-8 assay. Compounds 8, 10, 13, 17 and 20 showed strong cytotoxic activities against the tested cancer cell lines (IC_ (50) <3 μmol / L). In addition, these compounds showed weak cytotoxic effects on human epithelial prostate normal cells WPMY-1. The structure-activity relationship (SAR) of these arylpiperazine derivatives was also discussed based on the obtained experimental data.
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