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目的 :探讨玄参升麻汤联合复方甲氧那明治疗儿童慢性咳嗽的临床疗效观察。方法 :将88例慢性咳嗽患儿分为观察组和对照组,每组44例。对照组口服复方甲氧那明片。观察组在对照组基础上,给予玄参升麻汤。于治疗前后检测患者血清指标(TNF-a、IL-6、Ig E)及肺功能指标(FVC、PEF、TLC、FEV1)的变化。结果 :观察组的治疗效果比对照组好,差异有统计学意义;两组治疗后TNF-a、IL-6、Ig E的水平较治疗前均明显降低;治疗后,观察组的TNF-a、IL-6、Ig E明显低于对照组,差异有统计学意义;两组治疗后FVC、PEF、TLC、FEV1的水平较治疗前均明显升高;治疗后,观察组FVC、PEF、TLC、FEV1的显著高于对照组,差异有统计学意义。结论 :玄参升麻汤联合复方甲氧那明能显著减轻儿童慢性咳嗽的炎症反应,改善肺功能。
Objective: To investigate the curative effect of Fufangshuixinmang Decoction combined with compound methoxyphenamine on children with chronic cough. Methods: 88 cases of chronic cough children were divided into observation group and control group, 44 cases in each group. The control group oral compound metoprolol tablets. Observation group on the basis of the control group, given Scrophulariaceae Cimicifuga soup. Serum parameters (TNF-α, IL-6, Ig E) and pulmonary function parameters (FVC, PEF, TLC, FEV1) were measured before and after treatment. Results: The treatment effect of the observation group was better than that of the control group, the difference was statistically significant. After treatment, the levels of TNF-a, IL-6 and Ig E in the two groups were significantly lower than those before treatment; after treatment, the levels of TNF- , IL-6 and Ig E in the observation group were significantly lower than those in the control group, and the difference was statistically significant. The levels of FVC, PEF, TLC and FEV1 in both groups were significantly higher than those before treatment; after treatment, FVC, PEF, TLC , FEV1 was significantly higher than the control group, the difference was statistically significant. Conclusion: Scrophulariaceae Cimicifuga combined with triamcinolone acetonide can significantly reduce the inflammatory reaction of chronic cough in children and improve pulmonary function.