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目的:检测不同年龄组肺炎支原体肺炎(MPP)患儿WBC、CRP、PCT水平的变化情况,分析不同年龄组患儿MP的药敏情况,探讨其临床意义。方法:对已确诊为MPP的108例患儿按年龄分为婴幼儿组、学龄前期组和学龄期组,检测血中WBC、CRP和PCT水平,分别比较各项指标在不同年龄的差异,同时分析各组患儿对阿奇霉素、喹诺酮类与红霉素的敏感性。结果:各年龄组患儿WBC、CRP和PCT水平均有升高,两两比较差异有统计学意义(P<0.05)。婴幼儿组与学龄前期组、婴幼儿组与学龄期组、学龄前期组与学龄期组患儿MP对阿奇霉素、喹诺酮类、红霉素药敏情况比较差异无统计学意义(P>0.05);阿奇霉素与红霉素、喹诺酮类与红霉素各年龄组药敏情况比较差异有统计学意义(P<0.05)。各年龄组患儿MP对阿奇霉素和喹诺酮类抗菌药物均较敏感,而对红霉素的敏感性则较低。结论:对于MPP患儿应及时行CRP、PCT和WBC检测,早期使用阿奇霉素治疗小儿MPP,可以有效提高治疗效果。
OBJECTIVE: To detect the changes of WBC, CRP and PCT levels in children of different ages with mycoplasma pneumoniae (MPP) and to analyze the drug susceptibility of MP in children of different age groups and to explore its clinical significance. Methods: 108 infants diagnosed as MPP were divided into infants group, preschool group and school-age group according to their age. WBC, CRP and PCT levels in blood were detected, and the differences of each index were compared at different ages The sensitivity of azithromycin, quinolone and erythromycin in children in each group was analyzed. Results: The levels of WBC, CRP and PCT in children of all age groups were increased, with a significant difference between every two groups (P <0.05). There was no significant difference in the antimicrobial susceptibility between azithromycin, quinolone and erythromycin in infant group, preschool group, infant group and school - age group, preschool group and school age group (P> 0.05). Azithromycin and erythromycin, quinolones and erythromycin drug sensitivity in all age groups were statistically significant differences (P <0.05). MP in all age groups were more sensitive to azithromycin and quinolone antibiotics but lower to erythromycin. Conclusion: For children with MPP, CRP, PCT and WBC tests should be performed in time. Early use of azithromycin in children with MPP can effectively improve the therapeutic effect.