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在大鼠孕４ ｄ 宫腔内一次性注入钙调素特异性拮抗剂—三氟拉嗪（ＴＦＰ），每侧子宫角０．０５ｍ Ｌ（内含０．２５ ｍ ｇ），具有显著的抗着床作用，抗着床率高达１００％ ，而注入等容量生理盐水的对照组为０％ ．应用放射免疫测定技术发现，该剂量的ＴＦＰ能显著降低血清中孕酮（Ｐ）的含量，但对雌二醇（Ｅ２）则无明显影响，也不影响卵巢重及黄体数量．宫内注入ＴＦＰ能抑制假孕致蜕膜化反应，抑制程度与药量有关．结果表明，钙调素（ＣａＭ）在着床过程中起重要作用，此作用与血清孕酮水平有关，ＣａＭ 参与子宫内膜蜕膜化过程，而与血清中雌激素浓度无直接关系．
In the fourth trimester of pregnancy, the calmodulin-specific antagonist trifluoperazine (TFP) was injected into the uterine cavity at a dose of 0.05 m L (0.25 m g each) with significant anti-tumor activity Implantation effect, anti-implantation rate as high as 100%, while injecting equal volume of saline control group was 0%. Using radioimmunoassay, TFP at this dose significantly reduced serum progesterone (P) levels but had no significant effect on estradiol (E2) nor the number of ovaries and corpus luteum. Intrauterine injection of TFP can inhibit pseudo-pregnancy induced decidualization, the degree of inhibition and dose. The results showed that calmodulin (CaM) plays an important role in the process of implantation. The effect is related to the level of serum progesterone. CaM is involved in the process of decidualization of the endometrium, but not directly related to the serum estrogen concentration.