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干扰素的全身性副作用较常见。作者曾遇见过1例在干扰素治疗中突然发生感觉神经性听觉的丧失。为此，作者进行了一项前瞻性随访，报告了干扰素的耳毒性作用。共49例患者接受干扰素治疗。其中22例慢性乙型或慢性丙型肝炎患者接受α-干扰素（EFNα）治疗，包括天然的原始林巴细胞
The systemic side effects of interferon are more common. The authors have seen 1 case of a sudden loss of sensory neuropathy in interferon therapy. To do this, the authors conducted a prospective follow-up to report the ototoxic effects of interferon. A total of 49 patients received interferon treatment. Twenty-two patients with chronic hepatitis B or chronic hepatitis C received treatment with interferon-alpha (EFNα), including native primate cells