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目的:探讨甲基强的松龙和环磷酰胺双击治疗儿童紫癜性肾炎的临床疗效。方法:自2011年1月至2013年12月我院共收治紫癜性肾炎患儿56例,按照随机自愿的原则分为对照组和观察组,对照组患儿采用基础治疗与甲基强的松龙冲击治疗,治疗组在对照组的基础上加用环磷酰胺冲击治疗,治疗四周后观察两组治疗情况以及不良反应状况。结果:治疗组的显效率为46.43%,有效率为92.86%均显著高于对照组的显效率(25.00%)和有效率(64.29%);治疗组发生19例不良反应,对照组发生27例不良反应,对照组不良反应发生情况高于观察组。结论:采用甲基强的松龙和环磷酰胺双击治疗紫癜性肾炎,可发挥协同作用,能够有效改善患者临床症状,减少不良反应,为临床治疗儿童紫癜性肾炎提供了一条新的治疗方法。
Objective: To investigate the clinical efficacy of methylprednisolone and cyclophosphamide double-click in the treatment of purpuric nephritis in children. Methods: From January 2011 to December 2013, 56 cases of children with purpura nephritis were treated in our hospital. According to the principle of randomness and voluntariness, we divided them into control group and observation group. The control group received basic treatment with methylprednisolone Long shock treatment, the treatment group on the basis of the control group plus cyclophosphamide shock treatment, after treatment for four weeks to observe the treatment and adverse reactions. Results: The effective rate of treatment group was 46.43%, the effective rate was 92.86%, which was significantly higher than that of control group (25.00%) and effective rate (64.29%). There were 19 adverse reactions in treatment group and 27 cases in control group Adverse reactions, adverse reactions in the control group than in the observation group. Conclusion: The treatment of purpuric nephritis with methylprednisolone and cyclophosphamide double-double treatment can play a synergistic effect, which can effectively improve the clinical symptoms and reduce adverse reactions in patients with purpura nephritis. It provides a new treatment for the treatment of purpuric nephritis in children.