神经管畸形是一组常见的、后果极为严重的出生缺陷,在中国已成为围产儿死亡的主要原因〔1〕。有研究表明,孕妇在孕期增补叶酸可有效预防神经管畸形的发生〔2-3〕。近年来,世界各国均积极采取相应措施在育龄妇女中推广叶酸,但服用现状较差,能在适宜时间段服用者更少,严重影响了出生缺 Neural tube deformity is a common and very serious consequence of birth defects, which has become the leading cause of perinatal death in China [1]. Studies have shown that pregnant women add folic acid during pregnancy can effectively prevent the occurrence of neural tube defects 〔2-3〕. In recent years, all countries in the world have taken active measures to promote folic acid among women of childbearing age. However, their taking status quo is relatively poor and they can take fewer doses in the appropriate time, seriously affecting the birth defects