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肥胖作为各种心脑血管粥样硬化性疾病的独立危险因素，可通过脂肪组织堆积、分泌各种活性因子、激活氧化应激、脂质代谢紊乱等方面促进血管粥样硬化的发生、发展，增加心脑血管疾病的发病率和病死率。血脂异常特别是高密度脂蛋白胆固醇（ HDL-C）的减少与血管粥样硬化的发生密切相关。目前关于肥胖导致HDL-C减少的机制尚未完全明确，因此研究肥胖与 HDL-C 代谢的影响可帮助深入了解脂质代谢过程和动脉粥样硬化（ AS）的发展机制。“,”Obesity,as the independent risk factor of atherosclerotic cardiovascular disease ,can promote the occurrence of atherosclerosis development and increase the morbidity and mortality of cardiovascular by adipose tissue accumulation,the secretion of various active factors ( adiponectin, angiotensin, interleukin, etc.), activation of oxidative stress and lipid metabolism disorders, etc.Among them, dyslipidemia, espe-cially high-density lipoprotein (HDL-C) and the incidence of atherosclerosis is closely related.However, the mechanisms underlying obesity and low HDL-C have not been fully elucidated.Therefore, the study of o-besity and metabolism of HDL-C can help in-depth understanding of lipid metabolism and AS development mechanism.