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1964年,Hoffman和Granefield提出,心律失常的发生是由于异常冲动形成、传导障碍或两者兼有所致。随后,对心律失常的发生机制和抗心律失常药的作用原理,做了大量的研究工作。并根据药物对心肌电生理的影响进行了分类,促进和指导了抗心律失常药的研究和临床用药。一、心律失常的发生机制临床上心律失常发生的机制有自律性、后电位触发与折返。心肌细胞的自律性增加,可由于突性冲动增快或异位冲动的产生而形成。交感神经张力增高,心肌缺血缺氧,洋地黄中毒等,使心肌细胞内钙增多,钠钾减少而诱发心律失常。在心肌细胞除极
In 1964, Hoffman and Granefield proposed that arrhythmias occur as a result of abnormal impulsivity, conduction disturbances, or both. Subsequently, a large amount of research work has been done on the mechanism of arrhythmia and the action principle of anti-arrhythmic drugs. And according to the impact of drugs on myocardial electrophysiology were classified to promote and guide the antiarrhythmic drug research and clinical medication. First, the mechanism of arrhythmia Clinical arrhythmia occurs in a self-regulatory mechanism, after the potential trigger and reentry. Cardiomyocytes increased self-discipline may be due to sudden impulsive or ectopic impulse to accelerate the formation of the formation. Increased sympathetic tone, myocardial ischemia and hypoxia, digitalis poisoning, increased intracellular calcium, sodium and potassium decreased induced arrhythmia. Depolarization in cardiomyocytes