论文部分内容阅读
以荷瘤动物模型观察固金磨积片的抑瘤作用及其对免疫功能的影响。结果：固金磨积片高、中、低剂量对小鼠肉瘤１８０（Ｓ１８０）抑瘤率分别为４９．１７５％、４８．５１５％和４１．５８４％，与生理盐水组比较有显著性差异（Ｐ＜０．０５）；对小鼠肝癌腹水型（ＨｅｐＡ）的生命延长率达３６．４％～５７．１％（Ｐ＜０．０１）；能使化疗荷瘤小鼠免疫器官胸腺、脾脏的重量，胸腺重／体重的比值回升；促进荷瘤小鼠血清抗体（溶血素）的生成作用；提高外周血Ｔ淋巴细胞（Ｔ）、辅助性Ｔ细胞（Ｔｈ）的百分数，纠正Ｔｈ／Ｔｓ（Ｔｓ为抑制性Ｔ细胞的英文缩写）的比值异常，拮抗化疗药ＦＴ＿２０７对此类细胞的抑制作用，提高自然杀伤细胞（ＮＫ）的活性。
Tumor-bearing animal model was used to observe the anti-tumor effect of Gujin Grinding Tablet and its effect on immune function. RESULTS: The tumor inhibition rates of high-, medium-, and low-dose Gujin rubbing tablets against mouse sarcoma 180 (S180) were 49.175%, 48.515%, and 41.584%, respectively, which were significantly different from the saline group. (P<0.05); The survival rate of ascites type HepA in mice was 36.4%-57.1% (P<0.01); The weight of spleen and the ratio of thymus weight/body weight rebound; promote the production of serum antibody (hemolysin) in tumor-bearing mice; increase the percentage of T lymphocytes (T) and helper T cells (Th) in peripheral blood and correct Th/ The ratio of Ts (Ts is the English abbreviation for suppressor T cells) is abnormal, which antagonizes the inhibitory effect of chemotherapeutic drug FT_207 on such cells and increases the activity of natural killer (NK) cells.