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以荷瘤动物模型观察固金磨积片的抑瘤作用及其对免疫功能的影响。结果:固金磨积片高、中、低剂量对小鼠肉瘤180(S180)抑瘤率分别为49.175%、48.515%和41.584%,与生理盐水组比较有显著性差异(P<0.05);对小鼠肝癌腹水型(HepA)的生命延长率达36.4%~57.1%(P<0.01);能使化疗荷瘤小鼠免疫器官胸腺、脾脏的重量,胸腺重/体重的比值回升;促进荷瘤小鼠血清抗体(溶血素)的生成作用;提高外周血T淋巴细胞(T)、辅助性T细胞(Th)的百分数,纠正Th/Ts(Ts为抑制性T细胞的英文缩写)的比值异常,拮抗化疗药FT_207对此类细胞的抑制作用,提高自然杀伤细胞(NK)的活性。
Tumor-bearing animal model was used to observe the anti-tumor effect of Gujin Grinding Tablet and its effect on immune function. RESULTS: The tumor inhibition rates of high-, medium-, and low-dose Gujin rubbing tablets against mouse sarcoma 180 (S180) were 49.175%, 48.515%, and 41.584%, respectively, which were significantly different from the saline group. (P<0.05); The survival rate of ascites type HepA in mice was 36.4%-57.1% (P<0.01); The weight of spleen and the ratio of thymus weight/body weight rebound; promote the production of serum antibody (hemolysin) in tumor-bearing mice; increase the percentage of T lymphocytes (T) and helper T cells (Th) in peripheral blood and correct Th/ The ratio of Ts (Ts is the English abbreviation for suppressor T cells) is abnormal, which antagonizes the inhibitory effect of chemotherapeutic drug FT_207 on such cells and increases the activity of natural killer (NK) cells.