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目的:探讨凋亡抑制基因Survivin在口腔鳞癌组织中的表达及其与COX-2表达的相关性。方法:运用S-P免疫组化技术,检测Survivin和COX-2蛋白在50例口腔鳞癌组织、10例正常口腔黏膜组织中的阳性率。结果:Survivin蛋白在10例正常口腔黏膜组织中呈阴性,而在50例口腔鳞癌组织中有42例阳性,占84%,差异有极显著性差异(P<0.01),COX-2蛋白在口腔鳞癌组织中的阳性率为86%(43/50)。Survivin蛋白阳性率与年龄和性别不相关,而与COX-2蛋白阳性呈正相关(P<0.05)。Survivin蛋白在低分化癌组织中的表达比在高分化癌中高,但在统计学上无明显差异性。结论:肿瘤组织中Survivin蛋白的高阳性表达对口腔鳞癌的发生发展起重要作用;COX-2蛋白在口腔鳞癌组织中也有高阳性表达,并与Survivin有相关性。两者可能存在共同的激活机制,从而抑制口腔鳞癌细胞的凋亡。
Objective: To investigate the expression of survivin gene in oral squamous cell carcinoma and its correlation with the expression of COX-2. Methods: The positive rates of Survivin and COX-2 protein in 50 cases of oral squamous cell carcinoma and 10 cases of normal oral mucosa were detected by S-P immunohistochemistry. Results: Survivin protein was negative in 10 cases of normal oral mucosa tissues, 42 of 50 cases of oral squamous cell carcinoma were positive (84%), the difference was statistically significant (P <0.01). The expression of COX-2 protein in The positive rate in oral squamous cell carcinoma was 86% (43/50). The positive rate of Survivin protein was not related to age and sex, but positively correlated with COX-2 protein (P <0.05). The expression of Survivin protein in poorly differentiated carcinoma was higher than that in well differentiated carcinoma, but there was no statistically significant difference. CONCLUSIONS: High positive expression of Survivin protein in tumor tissue plays an important role in the development of oral squamous cell carcinoma. COX-2 protein is also highly expressed in oral squamous cell carcinoma and is correlated with Survivin. Both may have a common activation mechanism, thereby inhibiting oral squamous cell carcinoma apoptosis.