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目的:探讨不同剂量的多烯磷脂酰胆碱(易善复)对肝硬化的治疗效果及其安全性。方法:以2016年~2017年在我院就诊的70例单纯肝炎后肝硬化(VC)和酒精性肝硬化(AC)患者为研究对象,采用随机数字表法将其随机分为小剂量组和大剂量组,每组35例。小剂量组予易善复10 m L+5%葡萄糖注射液250 m L静滴,大剂量组予易善复20 m L+5%葡萄糖注射液250 m L静滴。观察两组治疗前后临床症状、血尿常规、肾功能、肝功能指标、腹腔彩超的变化情况。结果:两组患者治疗后肝功能指标谷丙转氨酶(ALT)、白蛋白(ALB)、总胆红素(TBIL)、谷草转氨酶(AST)、碱性磷酸酶(ALP)均较治疗前明显改善(P<0.05),且大剂量组各项指标水平均明显优于小剂量组(P<0.05);大剂量组治疗肝硬化的总有效率为88.6%,显著高于小剂量组的(68.6%,P<0.05)。两组治疗过程中均未见明显药物副反应。结论:与小剂量易善复相比,大剂量易善复更能改善单纯肝炎后肝硬化和酒精性肝硬化患者的肝功能,提高药物疗效的同时不增加药物副反应,安全性高。
Objective: To investigate the therapeutic effect and safety of different doses of polyene phosphatidylcholine (Yi Shan Fu) on cirrhosis. Methods: Seventy patients with posthepatitic cirrhosis (VC) and alcoholic cirrhosis (AC) who were treated in our hospital from 2016 to 2017 were randomly divided into two groups: small dose group High-dose group, 35 cases in each group. The low-dose group received 250 m L infusion of 10 m L + 5% glucose injection and the high dose group received 250 m L infusion of 20 m L + 5% glucose injection. The changes of clinical symptoms, hematuria, renal function, liver function and abdominal ultrasonography were observed before and after treatment. Results: After treatment, the indexes of ALT, ALB, TBIL, AST and ALP in both groups were significantly improved after treatment (P <0.05). The indexes of high-dose group were significantly better than those of low-dose group (P <0.05). The total effective rate of high-dose group was 88.6%, significantly higher than that of low-dose group %, P <0.05). No significant side effects were observed in the two groups during the course of treatment. Conclusion: Compared with low-dose Yi-Fu-Fu, high-dose Yi-Fu-Fu can improve liver function in cirrhotic patients with cirrhosis and alcohol-induced cirrhosis alone, and improve the efficacy of drugs without increasing the side effects of drugs.