食管癌是我国高发的恶性肿瘤,恶性度高,5年生存率仅20%左右,但其病因和发病机制尚不明确,可能与原癌基因激活、抑癌基因失活以及细胞凋亡相关基因和肿瘤转移抑制基因异常等有关[1]。因此,加强对食管癌特异的分子病理学变化的研究,不仅有助于阐明其发生、发展的机制,而且更利于 Esophageal cancer is a malignant tumor with high incidence in our country. The 5-year survival rate is only about 20%. However, the etiology and pathogenesis of esophageal cancer is not clear, which may be related to the activation of oncogenes, inactivation of tumor suppressor genes and apoptosis-related genes And tumor metastasis suppressor gene abnormalities [1]. Therefore, to strengthen the esophageal cancer-specific molecular pathological changes, not only help to clarify the mechanism of its occurrence and development, but also more conducive