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应用心钠素快速放射免疫分析法,初步观测了先天性心脏病患者心导管检查过程中腔静脉、右心房下部、右心室流出道及股动脉内血浆心钠素浓度并与周围静脉比较,以探讨血液循环中心钠素的主要来源。结果表明,先天性心脏病患者周围静脉及腔静脉血浆心钠素浓度较正常对照组明显升高(P<0.05)。右心房下部血浆心钠素浓度与右心室流出道及股动脉比较无明显差别。但三者均较腔静脉及周围静脉血浆心钠素浓度显著增高(P<0.05),提示人体循环血浆心钠素主要来源于心房。本研究结果支持心脏具有内分泌功能的学说。
The atrial natriuretic peptide, the lower right atrium, the right ventricular outflow tract and the femoral artery plasma atrial natriuretic peptide concentrations in cardiac catheterization were compared with those in the peripheral vein To explore the main source of atrial natriuretic peptide in the blood circulation. The results showed that plasma atrial natriuretic peptide concentrations in peripheral veins and vena cava in congenital heart disease patients were significantly higher than those in normal controls (P <0.05). The right atrial lower plasma atrial natriuretic peptide concentration and right ventricular outflow tract and femoral artery compared with no significant difference. However, the plasma atrial natriuretic peptide concentrations in all three groups were significantly higher than those in the vena cava and peripheral venous blood (P <0.05), suggesting that the plasma atrial natriuretic peptide mainly comes from the atrium. The results of this study support the theory that the heart has endocrine function.