【摘 要】
:
Objective:To investigate whether Shenfu Injection (SFI,参附注射液) can alleviate post-resuscitation myocardial dysfunction by inhibiting the inflammatory response.Methods:After 8 min of ventricular fibrillation and 2 min of basic life support,24 pigs were rand
【机 构】
:
Department of Emergency Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing Key
论文部分内容阅读
Objective:To investigate whether Shenfu Injection (SFI,参附注射液) can alleviate post-resuscitation myocardial dysfunction by inhibiting the inflammatory response.Methods:After 8 min of ventricular fibrillation and 2 min of basic life support,24 pigs were randomly divided into 3 groups (n=8),which were given intravenous bolus injections of SFI (1.0 mL/kg),epinephrine (EP,0.02 mg/kg) and normal saline(SA),respectively.The animals were sacrificed at 24 h after restoration of spontaneous circulation (ROSC),and serum interleuking-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels were measured by enzyme-linked immunosorbent assay (ELISA);expressions of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κ B)mRNAs and proteins were determined by RT-PCR and Western blot,respectively.Results:Compared with the EP and the SA groups,the ultrastructure of myocardial cells were slightly damaged and the systolic function of the left ventricle was markedly improved in the SFI group at 24 h after ROSC (P<0.05).In addition,compared with the EP and SA groups,the SFI group also showed significantly reduced levels of serum IL-6 and TNF-α,protein and mRNA levels of myocardial NF-κ B and TLR4 (P<0.05).Conclusions:Activation of TLR4/NF-κ B signaling pathway may be involved in the pathological mechanisms of post-resuscitation myocardial dysfunction.SFI may block NF-κ B-mediated inflammatory response by reducing the activity of NF-κ B and the level of TNF-α,thus playing a protective role in post-resuscitation myocardial dysfunction.
其他文献
Upon his untimely death,Michal Boym (1612-1659) left behind an enormous written legacy;covering a diverse range of interests in fields such as Chinese linguistics,cartography,botany,zoology,philosophy and medicine.This article attempts to examine Boym\'
Objective:To assess the trends in characteristics,treatments,and outcomes of acute myocardial infarction (AMI) patients in tertiary Chinese medicine (CM) hospitals in China between 2006 and 2013.Methods:This retrospective study was based on two nationwide
Biological complexity and the need for personalized medicine means that biomarker development has become increasingly challenging.Thus,new paradigms for research need to be created that bring together a different classifier of individuals.One potential so
Objective:To explore the effect of low-frequency magnetic stimulation at Shenmen(HT 7)acupoint on blood oxygen levels in the prefrontal cortex of healthy subjects.Methods:Functional near-infrared spectroscopy(fNIRS)technology was used to collect real-time
Objective:To evaluate the safety and effectiveness of Qishe Pill(芪麝丸) on neck pain in real-world clinical practice.Methods:A multi-center,prospective,observational surveillance in 8 hospitals across Shanghai was conducted.During patients receiving 4-week
Objective:To observe the effects and safety of Tongyan Spray(通咽喷雾剂) on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia.Methods:Seventy-two patients with ischemic post-strokedysphagia were selected and randomly assigned t
Background:Antiviral therapy can lead to regression of fibrosis in chronic hepatitis B (CHB),but it has a limited effect on cirrhosis.Chinese medicines (CMs),particularly Fuzheng Huayu Tablet(扶正化瘀片,FZHY),have an antifibrotic effect in patients with CHB.Ob
From the perspective view of Chinese medicine,the Gan (Liver) meridian of Foot-Jueyin starts from the great toe,running upward along the medial side of the thigh to the perineal area,where it curves around the external genitalia and goes up to the lower a
Objective:To investigate the protective effects of Shexiang Tongxin Dropping Pill(麝香通心滴丸,STDP) following sodium laurate-induced coronary microembolization (CME) in rats.Methods:Forty rats were divided int04 groups:the control (sham) group,CME group,low-do
Objective:To study the use of Chinese medicine (CM) in cancer patients in southern China.Methods:A total of 1,950 cancer patients finished questionnaires in four provinces in southern China.The survey included socio-demographic and clinical characteristic