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选用一组国产敏感特异的McAb,采用APAAP桥联免疫酶标组化染色技术对40例形态学和免疫学分型不一致的急性白血病进行了分析。结果表明,32例形态学难以分类或虽能分类但与免疫学分型不同的急性白血病均有明确的细胞系列特异性标记表达。其中B-ALL14例、T-ALL1例、ANLL2例、同时表达T和B系相关分化抗原的双标-ALL 11例、HAL4例,同时表达淋巴和髓系相关的特异性标记。有8例未测到任何标记抗原,归属于急性未分化型白血病。
A group of domestic-specific and sensitive McAbs were selected and 40 cases of acute leukemia with different morphological and immunological genotypes were analyzed by APAAP. The results showed that 32 cases of morphologically difficult to classify or classification, but with different immunological classification of acute leukemia have clear cell line-specific marker expression. There were 14 cases of B-ALL, 1 case of T-ALL and 2 cases of ANLL. There were 11 cases of double-labeled ALL and 6 cases of HAL related to differentiated T and B-related differentiation antigen, and lymphatic and myeloid specific markers were also expressed. In 8 cases, no labeled antigen was detected and was attributed to acute undifferentiated leukemia.