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目的:研究大果阿魏的抗凝血作用。方法:Wistar大鼠随机分为6组,大果阿魏高剂量组100 mg·kg~(-1),中剂量组50 mg·kg~(-1),低剂量组25 mg·kg~(-1),中药阳性药物对照组银杏叶片144μg·kg~(-1),西药阳性药物对照组华法林125μg·kg~(-1),空白溶剂对照组给予等容量的生理盐水,连续灌胃7 d。测定大鼠活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)及复钙时间(RT),观察大果阿魏的抗凝血作用。结果:高、中、低三个剂量组的大果阿魏均能明显延长大鼠血浆APTT、PT、TT和RT时间。与溶剂对照组比较,差异均有统计学意义(P<0.05或P<0.01)。结论:大果阿魏具有显著的抗凝血作用。
Objective: To study the anticoagulant effect of Fructus-nigra. Methods: Wistar rats were randomly divided into 6 groups: high-dose ferulicose 100 mg·kg -1, medium-dose 50 mg·kg -1, and low-dose 25 mg·kg -1 -1), Ginkgo biloba leaves (144 μg·kg -1 ) in the positive control group of traditional Chinese medicine, Warfarin (125 μg·kg -1 ) in the Western drug positive control group, and normal saline of equal volume in the blank solvent control group. Stomach 7 d. The activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and recalcification time (RT) were measured to observe the anticoagulant effect of Fructus. RESULTS: The high, middle, and low doses of A. canaliculata significantly prolonged APTT, PT, TT, and RT time in rat plasma. Compared with the solvent control group, the differences were statistically significant (P<0.05 or P<0.01). Conclusion: The fruit of Fructus Arundinacea has a significant anticoagulant effect.