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目的:分析住院结核病患者抗结核药物如异烟肼(H)、利福平(R)、乙胺丁醇(E)、吡嗪酰胺(Z)、利福喷丁(RFT)、利福布丁(RFB)、注射用抗结核药链霉素(S)、卡那霉素(KM)等致药物不良反应(ADR)的发生原因、特点及其预防对策。方法:抽取2013年8月—2016年8月间使用抗结核药物治疗的住院结核病患者60例资料,根据患者的病例信息,分析抗结核药物所致药物不良反应(ADR)的发生的原因、特点。结果:60例结核病患者中,其中抗结核药物致不良反应31例,其发生率为51.67%;用药期间患者发生1种ADR的发生率高于2种和多种不良反应发生率(P<0.05);不良反应症状常见的有胃肠道反应、肝功能异常、神经系统损伤、关节痛和过敏反应等。结论:结核病患者抗结核药物治疗致不良反应的发生较多,治疗期间应监测其用药,判断并调整治疗方案,预防严重的不良反应的发生。
OBJECTIVE: To analyze the prevalence of anti-tuberculosis drugs in hospitalized patients with tuberculosis such as isoniazid (H), rifampin (R), ethambutol (E), pyrazinamide (Z), rifapentine (RFT) (RFB), injection of anti-TB streptomycin (S), kanamycin (KM) and other drug-induced adverse reactions (ADR) causes, characteristics and preventive measures. Methods: Sixty patients with tuberculosis in our hospital from August 2013 to August 2016 were enrolled. According to the patient’s case information, we analyzed the causes and characteristics of the ADR caused by anti-tuberculosis drugs . Results: Of the 60 TB patients, 31 cases were adverse reactions caused by anti-tuberculosis drugs, and the incidence rate was 51.67%. The incidence of 1 ADR was higher than that of 2 kinds and a variety of adverse reactions during the medication (P <0.05 ); Adverse reactions Symptoms Common gastrointestinal reactions, abnormal liver function, nervous system damage, joint pain and allergic reactions. Conclusion: Tuberculosis patients have more adverse reactions caused by antituberculous drugs treatment. During the treatment period, their medication should be monitored, the treatment plan should be judged and adjusted, and serious adverse reactions should be prevented.