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与非糖尿病(NDM)个体相比,糖尿病(DM)患者体内多种蛋白质可发生糖化作用,其中部分糖化蛋白质被认为与DM慢性并发症有关[1-2]。在众多的糖化蛋白质中,糖化血红蛋白(HbA1c)被认为是判断DM患者血糖控制水平的金指标[3-4]。糖尿病控制与并发症试验(DCTT)研究结果认为,HbA1c<7.0%是用于判断DM慢性并发症的理想指标[5]。红细胞的生存周期一般为120d,因此HbA1c水平反映的是几个月前的血糖含量[6]。
Glycosylation occurs in a variety of proteins in patients with diabetes mellitus (DM) compared with non-diabetic (NDM) individuals, and some glycosylated proteins are considered to be associated with chronic complications of DM [1-2]. Glycated hemoglobin (HbA1c) is considered as the gold index for determining glycemic control in DM patients in many glycated proteins [3-4]. Diabetes Control and Complications Trial (DCTT) study concluded that, HbA1c <7.0% is an ideal indicator for judging the chronic complications of DM [5]. The life cycle of red blood cells is generally 120d, so the level of HbA1c reflects the blood sugar levels a few months ago [6].