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To realize effective cancer immunotherapy,Ding et al.constructed a structurally well-defined DNA-based nanodevice to quantitatively assemble cancer cell-specific antigen and multiple adjuvants as a cancer vaccine.This nanodevice vaccine can efficiently accumulate in the draining lymph nodes and respond to the endosomal acidic envi-ronment of dendritic cells to release the antigen and adjuvants.These active payloads stimulate dendritic cells maturation and antigen presentation to elicit a robust,antigen-specific cytotoxic T-lymphocyte response to kill cancer cells.This work has been published online in the Nature Materials on Sept.7,2020.