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目的探讨ACE基因插入/缺失(D/I)多态性在海南汉族高血压颈动脉粥样硬化中的意义。方法采用PCR方法对ACE基因D/I多态性进行检测,观察DD、DI、II基因型频率及其等位D、I基因频率,同时检测其血脂、载脂蛋白、血压及颈动脉硬化状况等指标,分析引起颈动脉粥样硬化的危险因素。结果两组间DD、DI、II基因型频率及D、I等位基因频率均无显著性差异;多元逐步回归分析显示,TG、高血压、ApoA是引起颈动脉粥样硬化的主要危险因素。结论ACE基因多态性与颈动脉粥样硬化无关。
Objective To investigate the significance of ACE gene insertion / deletion (D / I) polymorphism in carotid atherosclerosis of hypertension in Hainan Han nationality. Methods The D / I polymorphism of ACE gene was detected by PCR. The frequencies of DD, DI, II genotypes and their D, I gene frequencies were examined. The levels of lipids, apolipoproteins, blood pressure and carotid atherosclerosis And other indicators, analysis of risk factors leading to carotid atherosclerosis. Results There was no significant difference in the frequencies of DD, DI and II genotypes and the frequency of D and I alleles between the two groups. Multivariate stepwise regression analysis showed that TG, hypertension and ApoA were the major risk factors for carotid atherosclerosis. Conclusion ACE gene polymorphism has no relation with carotid atherosclerosis.