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[目的]探讨经后路椎体间植骨融合椎弓根钉内固定治疗腰椎失稳的临床疗效.[方法]对37例腰椎失稳的患者采用后路椎管、神经根管减压,椎弓根钉内固定,自体骨植骨治疗,并对术后植骨融合和手术效果进行评价.[结果]所有患者均获得随访,随访时间12～32个月(平均25个月).术后融合情况:优29例,良8例;优良率100%.根据JOA标准疗效评定结果:术后JOA评分较术前明显增高(P<0.05),术后优良率为92.9%,所有病例尤螺钉折断、松动,无植骨块脱出、塌陷、移位,无马尾神经损伤等并发症.[结论]经后路椎间植骨结合椎弓根钉内固定治疗腰椎小稳提高了融合成功率,降低了手术花费,达到稳定脊柱解除症状的目的,治疗效果满意.“,”[Objective]To investigate the clinical effect of treatment of lumbar vertebral instability with posterior intcrbody fusion using autogenous bone and pedicle screw fixation.[Methods]Thirty - seven cases of lumbar instability were treated with posterior spinal canal, nerve root canal decompression, pedicle screw fixation and autogenous bone grafting, and results were evaluated.[Results]Postoperative follow up time was average 25 months (ranged, 12 -32 months) . Excellent fusion was achieved in 29 cases and good fusion was achieved in 8 cases, with good - to - excellent rate of 100%. According to JOA standard efficacy evaluation, postoperative JOA score improved significantly than preoperative one (P<0. 05 ), with good -to -excellent rate of 92. 9%. No complication was found in all cases such as screw broken, screw loosening, plant bone prolapse, collapse, displacement, and cauda equine injury.[Conclusion]Posterior interbody fusion using autogenous bone and pedicle screw fixation is effective in treatment of lumbar vertebral instability.