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目的分析肝硬化患者凝血指标随肝功能损害程度的变化,并探讨其临床意义。方法测定肝硬化组(50例)和对照组(40例)血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB)。结果肝硬化组凝血指标与对照组比较,PT、APTT、TT均明显延长,差异有显著统计学意义(P<0.01),FIB明显下降,差异有统计学意义(P<0.05)。肝硬化失代偿组PT、APTT、TT及FIB与代偿组比较,差异有显著统计学意义(P<0.01)。结论凝血指标可以客观准确的评价肝硬化患者的凝血功能,能够发现早期肝病造成的凝血机制障碍,对肝硬化出血患者的抢救和治疗具有重要意义。
Objective To analyze the changes of coagulation index in cirrhotic patients with the degree of hepatic impairment, and to explore its clinical significance. Methods Plasma prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB) were measured in cirrhosis (50 cases) and control group (40 cases). Results Compared with the control group, the indexes of coagulation in cirrhosis group were significantly higher than those in control group (P <0.01). The FIB was significantly decreased (P <0.05). The differences of PT, APTT, TT and FIB between decompensated group and cirrhosis decompensated group were statistically significant (P <0.01). Conclusion The coagulation index can objectively and accurately evaluate the coagulation function of patients with cirrhosis, and can find the clotting mechanism obstacle caused by early liver disease, which is of great significance for the rescue and treatment of cirrhosis patients.