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目的:探讨γ-干扰素,干扰素诱导蛋白10(IP-10)在噬血细胞综合征(HPS)患者中的表达及意义。方法:采用EL ISA方法检测56例HPS患者血清γ-干扰素,IP-10表达。并设立无HPS的感染组35例和正常组20例作为对照。结果:除正常对照组外,感染患者血清γ-干扰素和IP10水平均升高,但是HPS患者升高非常明显。结论:感染性HPS中γ-干扰素明显升高刺激了IP-10的分泌,并有可能激活和募集更多T淋巴细胞,这些细胞因子的异常表达可能与HPS的病理机制有关。
Objective: To investigate the expression of interferon-γ (IFN-γ) and interferon-inducing protein 10 (IP-10) in patients with hemophagocytic syndrome (HPS). Methods: The serum levels of IFN-γ and IP-10 in 56 HPS patients were detected by ELISA. 35 cases of HPS-free infection group and 20 cases of normal group as control. Results: In addition to the normal control group, serum IFN-γ and IP10 levels in patients with infection were increased, but the HPS patients increased significantly. Conclusion: The significant increase of IFN-γ in infectious HPS stimulates the secretion of IP-10 and may activate and recruit more T lymphocytes. The abnormal expression of these cytokines may be related to the pathological mechanism of HPS.