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作者报告一例与Wood等描述的以甲巯丙脯酸治疗肝硬化腹水时引起的可逆性肾小球滤过率降低相类似的病例。女,65岁,因风心病充血性心衰入院。1979年做过二尖瓣修补术,但未能减低肺动脉压而曾有几次由于充血性心衰而需要住院治疗。1984年11月加用甲巯丙脯酸每日两次每25毫克,症状改善而无肾功能损害。患者以心衰再次住院、当时正服用速尿,甲巯丙脯酸25毫克每日二次,地戈辛,甲状腺素,Mianserin,华法令。并采用安体舒通100毫克日二次,速尿剂量从80增加到120毫克每日二次,未引起这一步利尿作用。入院后10天,采用了与速尿有协同作用的噻嗪类利尿剂甲苯喹唑磺胺,产生了
The authors report a case similar to that described by Wood et al. In a similar case of reversible glomerular filtration rate induced by hepatic cirrhosis with captopril. Female, 65 years old, admitted to hospital for rheumatic heart disease with congestive heart failure. Mitral valve repair was performed in 1979, but failed to reduce pulmonary arterial pressure and several times there was a need for hospitalization due to congestive heart failure. November 1984 plus captopril twice daily 25 mg, no improvement of renal function symptoms. Patients were hospitalized again with heart failure and were taking furosemide 25 mg twice daily, digoxigenin, thyroxine, Mianserin and warfarin. And spironolactone 100 mg twice daily, furosemide dose increased from 80 to 120 mg twice daily, did not cause this step diuretic effect. 10 days after admission, the use of a synergistic effect with furosemide thiazide diuretics toluolazine sulfa, produced